Cellosaurus Disease Terminology Depression Unipolar Depression C35094 Major Depressive Disorder Major Depression Mental or Behavioral Dysfunction Unipolar Depression Cellosaurus C3275630 Unipolar Depression A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts. Unipolar_Depression