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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
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    <!-- http://purl.obolibrary.org/obo/CL_0000165 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000165">
        <rdfs:label>neuroendocrine cell</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000324"/>
        <ns2:IAO_0000115>Neuroendocrine cells are cells that receive neuronal input (neurotransmitters released by nerve cells) and, as a consequence of this input, release message molecules (hormones) to the blood. In this way they bring about and integration between the nervous system and the endocrine system, a process known as neuroendocrine integration. An example of a neuroendocrine cell is the cell of the adrenal medulla (innermost part of the adrenal gland) which releases adrenalin to the blood. The adrenal medullary cells are controlled by the sympathetic division of the autonomic nervous system. These cells are modified postganglionic neurons. Autonomic nerve fibers lead directly to them from the central nervous system. The major center of neuroendocrine integration in the body is found in the hypothalamus and the pituitary gland. Here hypothalamic neurosecretory cells release factors to the blood. Some of these these factors, release at the median eminence, control the secretion of pituitary hormones, while others (the hormones oxytocin and vasopressin) are released directly to the peripheral circulation.</ns2:IAO_0000115>
        <ns3:NCI_Thesaurus_definition_citation>NCIt:C12485</ns3:NCI_Thesaurus_definition_citation>
        <ns2:IAO_0000115>A neuron that has the specialized function to produce and secrete hormones, and that constitutes, in whole or in part, an endocrine organ or system.</ns2:IAO_0000115>
        <ns2:IAO_0000117>Tomasz Adamusiak</ns2:IAO_0000117>
        <ns2:IAO_0000115>Neuroendocrine cells are cells that receive neuronal input (neurotransmitters released by nerve cells) and, as a consequence of this input, release message molecules (hormones) to the blood. An example of a neuroendocrine cell is the cell of the adrenal medulla which releases adrenalin to the blood. The major center of neuroendocrine integration in the body is found in the hypothalamus and the pituitary gland. Here hypothalamic neurosecretory cells release factors to the blood.</ns2:IAO_0000115>
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