hepatocyte The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. NCIt:C12588 A liver cell. The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. James Malone cell type