digestive system AE colorectal cancer metastatic AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/22642873 10052358 DJ, SS, YH a digestive system AE that has an outcome of cancer in the large intestine and the rectum. When metastatic, the cancer has already spead to distant sites and is considered stage IV. HPO: HP_0003003 SIDER: C0948380