has participant quality cardiovascular AE AE severity G1 AE severity G2 AE severity G3 AE severity G4 AE severity G5 Superior vena cava syndrome AE CTCAE: E13819 NCIt: C3396 MW, YH a cardiovascular AE that has obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache.