antibody test abnormal AE antinuclear antibody positive AE YH, KY In most cases, a positive ANA test indicates that your immune system has launched a misdirected attack on your own tissue — in other words, an autoimmune reaction. But some people have positive ANA tests even when they're healthy. Ref: http://www.mayoclinic.org/tests-procedures/ana-test/basics/definition/prc-20014566 ANA test abnormal AE URL: http://www.mayoclinic.org/tests-procedures/ana-test/basics/definition/prc-20014566 an antibody test abnormal AE that shows positive antinuclear antibody, which often attack a person's own cell nucleus.