part of part of develops_from cardial valve MA:0000086 UBERON:0000946 OpenCyc:Mx4rv8oyuJwpEbGdrcN5Y29ycA uberon stomodaeal valve UMLS:C0018826 FMA:7110 galen:HeartValve heart valves heart valve MESH:D006351 valve of heart A membranous fold of the heart that prevents reflux of fluid One of the four structures within the heart that prevent backflow of blood by opening and closing with each heartbeat. The valves include two semilunar valves, the aortic and pulmonary; the mitral or bicuspid valve; and the tricuspid valve. The valves permit blood flow in only one direction. [TFD][VHOG] XAO:0004126 TAO:0005065 GAID:176 cardiac valve heart valve EMAPA:17869 Rector et al: One might be tempted to define 'heart valve' equivalently to 'valve in the heart', and 'valve' as a 'structure which functions as a valve'. But this combination results in the 'foramen ovale' being classified as a kind of 'heart valve', since it is undoubtedly located in the heart and functions as a valve EV:0100024 VHOG:0000818 ZFA:0005065 BTO:0000564 Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[well established][VHOG] heart endocardial cushion valve mesoderm-derived structure neural crest-derived structure