part of
part of
develops_from
embryo
heart
endocardial cushion
(Cardiac valve formation in vertebrates) In response to a myocardial signal, endocardial cells at chamber boundaries take on a mesenchymal character, delaminate and migrate into the cardiac jelly. There, they form an endocardial cushion that is later remodelled into a valve.[well established][VHOG]
AV cushion
EHDAA2:0000434
EHDAA2:0004028
EHDAA:2586
EMAPA:16696
FMA:70302
GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form
MA:0000078
Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO]
TAO:0001317
The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA].
UBERON:0002062
VHOG:0000932
XAO:0004189
ZFA:0001317
atrioventricular canal cushion
atrioventricular cushion
cardiac cushion
endocardial cushion tissue
endocardial cushions
relationship loss: develops_from endocardial ring (TAO:0005072)[TAO]
uberon
endocardium
neural crest
trunk mesenchyme
cardiac mesenchyme
mesenchyme derived from neural crest