part of
part of
has part
has part
develops_from
contributes to morphology of
produces
abdomen
endocrine system
digestive system
bile
liver
AAO:0010111
All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG]
An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].
An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003).
BTO:0000759
CALOHA:TS-0564
EFO:0000887
EHDAA2:0000997
EHDAA:2197
EMAPA:16846
EV:0100089
FMA:7197
GAID:288
MA:0000358
MAT:0000097
MESH:D008099
MIAA:0000097
Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function.
OpenCyc:Mx4rvVimppwpEbGdrcN5Y29ycA
Organ which secretes bile and participates in formation of certain blood proteins.[AAO]
TAO:0000123
The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates.
UBERON:0002107
UMLS:C0023884
VHOG:0000257
XAO:0000133
ZFA:0000123
galen:Liver
hepatic
iecur
jecur
relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]
secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].
uberon
exocrine system
exocrine gland
immune system
hepatobiliary system
liver primordium
endoderm-derived structure
septum transversum
liver lobule
abdomen element
digestive gland
liver bud