has role is protonated form of secondary carboxamide organic heterotricyclic compound monocarboxylic acid amide difluorobenzene HIV-1 integrase inhibitor dolutegravir A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4<i>R</i>,12a<i>S</i>)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2<em>H</em>-pyrido[1',2':4,5]pyrazino[2,1-<em>b</em>][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. dolutegravir(1-)