located in has plasma membrane part capable of has low plasma membrane amount Kupffer cell Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. tissue-resident macrophage erythrocyte clearance integrin alpha-M adhesion G protein-coupled receptor E1 scavenger receptor cysteine-rich type 1 protein M130 macrosialin hepatic sinusoid