part of part of has part has part characteristic of has modifier Hyperproteinemia Elevated circulating cartilage oligomeric matrix protein concentration Cartilage oligomeric matrix protein (sCOMP) is physiologically located in the extracellular matrix (ECM) of cartilage tissue. It is assumed that sCOMP changes reflect the extrusion of COMP fragments of loaded cartilage tissue. The concentration of cartilage oligomeric matrix protein in the blood circulation is above the upper limit of normal. abnormal increased amount cartilage oligomeric matrix protein (human) blood