has characteristic has characteristic glioma low grade glioma Low-grade glioma may also be referred to as benign glioma. These tumors can be separated into two clinically distinct subgroups. The first group is of focal, well-circumscribed lesions that notably are not associated with an increased risk of malignant transformation. Recurrence rates are low, and the prognosis for these patients is excellent. Diffuse gliomas are WHO grade II lesions with a more infiltrative pattern of growth and high propensity for recurrence. The term "benign" is a misnomer in many of these cases, as the natural history of these tumors is with malignant transformation and recurrence as grade III or grade IV tumors. PMID:37452934 tumor grade 1 or 2, general grading system