has role has functional parent cyclomorusin A 418.440 6,11-dihydroxy-3,3-dimethyl-8-(2-methylprop-1-en-1-yl)-3H,7H,8H-chromeno[4,3-b]pyrano[2,3-h]chromen-7-one An extended flavonoid that is cyclomulberrin in which the hydroxy group at position 10 has undergone oxidative cyclisation to position 3 of the 3-methylbut-2-en-1-yl substituent, with migration of the double bond into conjugation with the aromatic ring. It is a moderate inhibitor of acetylcholinesterase (IC50 = 16.2 - 36.6 muM), and a strong inhibitor of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) induced platelet aggregation. C25H22O6 CAS:62596-34-3 CHEBI:132868 GDQXJMLXEYSICD-UHFFFAOYSA-N InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3 O1C=2C3=C(OC(C=C3)(C)C)C=C(O)C2C(=O)C=4C(OC5=C(C14)C=CC(O)=C5)C=C(C)C PMID:12648543 PMID:12662107 PMID:15884809 PMID:15885940 PMID:17396934 PMID:17405024 PMID:18330242 PMID:18608767 PMID:19149258 PMID:21434689 PMID:22145117 PMID:24381530 PMID:24494557 PMID:25981820 PMID:7903365 PMID:8435100 Reaxys:1442991 chebi_ontology cyclomorusin cyclomulberrin polyphenol organic heteropentacyclic compound EC 3.1.1.7 (acetylcholinesterase) inhibitor cyclic ketone platelet aggregation inhibitor EC 1.14.18.1 (tyrosinase) inhibitor extended flavonoid plant metabolite