part of part of has part has part participates in has...channel tropism 归...经 has..nature 具有...药性 has...flavour 具有...药味 has...toxicity 具有...毒性 has part Wilfordine (3bR,9bS)-6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e]isobenzofuran-1-one wilforine triptofordin C 2 celacinnine triptonide triptolidenol Wilforgine triptriolide neotriptophenolide triptonolide triptonoterpene triptotriterpenic acid A triptonoterpene methyl ether wilforidine celafurine triptonoterpenol triptohairic acid orthosphenic acid triptotriterpenic acid B triptotriterpenic acid C triptotritepenonic acid A regelin 6alpha-hydroxycholestanol 16-hydroxytriptolide triptophenolide methyl ether nicotinic acid vanillate sitosterol Celabenzine emodin (-)-epigallocatechin syringaresinol (-)-syringaresinol 3,4-dihydroxybenzaldehyde celastrol hypoglaunine B tripterifordin sciscllascilloside E-1 3-oxo-23-hydroxyurs-12-en-28-oic acid Euonymine nobiletin lacceroic acid tripdiolide triptolide ursolic acid Tripterygium wilfordii lactation factor of adverse event abdominal distension AE amenorrhoea AE aplastic anaemia AE dyspnea AE muscular weakness AE fever AE rash AE pruritus AE myalgia AE urticaria AE headache AE dizziness AE somnolence AE cough AE abdominal pain AE nausea and vomiting AE erythema multiforme AE liver function test abnormal AE jaundice AE palpitation AE increased salivation AE generalized spasm AE epistaxis AE ataxia AE edema AE inflammation AE mydriasis AE vomiting AE mouth mucosal ulceration AE diarrhea AE hematuria AE double vision AE ecchymosis AE skin ulceration AE blood bilirubin level increased AE bone marrow depression AE cardiac failure AE cardiogenic shock AE alcohol cardiomyopathy AE disturbance in attention AE drug eruption AE electrocardiogram result abnormal AE enteritis AE gastritis AE hematochezia AE hemolytic uremic syndrome AE hepatic failure AE hepatomegaly AE leukemoid reaction AE leukopenia AE myocarditis AE nephrotic syndrome AE pancytopenia AE pseudomembranous colitis AE red blood cell count decreased AE acute kidney injury AE thrombocytopenia AE upper gastrointestinal hemorrhage AE urine output decreased AE hypoactive sexual desire disorder AE chromatosis AE stomach ache AE photodermatitis AE interstitial nephritis AE herpes simplex AE albuminuria AE pain over the liver AE insomnia AE skin allergy AE obviously decreased blood pressure AE proarrhythmic effect AE low bone density AE generalised tonic-clonic seizure AE oligospermia AE aversion to greasy food AE lumbago AE kidney area percussion pain AE cylindruria AE hypomenorrhea AE necrospermia AE subfertility AE infertility AE low estrogen level AE dysfunctional uterine bleeding AE testicular atrophy AE pure red cell aplasia AE allergic cutaneous vasculitis AE melanoplakia AE erythema nodosum AE tonic spasm AE premature ovarian failure AE skin erosion AE root TCM winddamp-dispelling and heat-clearing drug 祛风湿清热药 Liver Meridian 肝经 Cold (TCD) 寒（中药） bitter (TCD) 苦（中药） Pungent (TCD) 辛（中药） Strong Toxicity 大毒 Kidney Meridian 肾经 Common Threewingnut Root TCD 徐国荣.雷公藤的临床应用与毒性反应及中毒解救[J]黑龙江中医药,2004,(3):50-51 邹爱英,刘秀书.雷公藤多苷片的不良反应及防治对策[J].天津药学,2008,20(1):25-26 马哲,梁茂新.中药雷公藤化学成分及药理作用研究进展,亚太传统医药,2011,7(3):157-160 文纪纯.雷公藤中毒致严重骨髓抑制6 例[J].海峡药学,1995,7(11):152 . 刘雪梅,刘志宏等.雷公藤临床应用及不良反应的研究进展[J] Jorunal of pharmaceutical practic,2015,33(2):110-113 柯坤字.雷公藤多苷片引起肝损害一例报告[J]实用临床医学杂志社,2009,10(7):40-42 张世应.雷公藤的毒性研究[J]Hubei Journal of TCM,2015,37(3):71-73 邱颖文 ,吴松武.雷公藤多苷的不良反应［Ｊ］西北药学杂志,2004,19(5):220-222 Yin chengxia. Literature analysis of 55 cases of adverse drug reaction by G lucoside tripterygium total[J]. Chinese Journal of Pharmacovigilance,2013,10(8):478-482 Gao yuping ,Chen defu. Clinical study on effect of Tripterygium wilfordii hook.f.on uterin leiomyoma[J] Chin J Obstet Gynecol,2000,35(7):430-432 Liu xumei,Liu zhihong, et al.Study progress on clinical application and side effects of Tripterygium wilfordii[J] Journal of pharmaceutical practice,2015,33(2):110-113 Tripterygii Radix et Rhizoma 唐永,张霞.雷公藤在皮肤科应用中的不良反应 (附 163 例临床分析 )[J]临床皮肤科杂志,1998,27(6):377 李平,陈钢.雷公藤的不良反应[J]药物不良反应杂志,2002,(4):238-240 张立放,杨淑清.雷公藤的不良反应[J].Journal of Mathematical Medicine,2003,16(5):442-443 张青.雷公藤治疗肾炎引起类白血病反应1 例报告[J].青海医药杂志,1997,10:60 万同己.雷公藤的不良反应[J]Practical Clinical Medicine,2005,6(6):149-150 Yu dihua,He dong-chu. Research progress on the toxicity of Tripterygium wilfordii and attenuated synergistic approaches[J].Medical recapitulate,2015,21(3):502-504 刘为萍,刘素香.雷公藤研究新进展[J]Chinese Traditional and Herbal Drugs,2010,41(7):1215-1218 高丽,白赟.雷公藤毒性反应研究进展[J].Chinese Journal of Information on TCM,2012,19(4):107-110 许杰州,黄少弼.雷公藤多贰的副作用12例报告[J]汕头大学医学院学报,1996(2):36-37 潘贵光,高文平.雷公藤多苷片致过敏反应１例[J].药物不良反应与相互作用,2003,21(1):52 Common Threewingnut Root 岳佳琦,韩相宁.雷公藤的不良反应[J]山东医药工业,2003,22(5):23-25 范兴忠, 陈勇, 李新东.雷公藤在免疫性疾病治疗中副作用的观察[ J] .中国中西医结合肾病杂志, 2001 , 2(2):83-85 谢宝官,钟文.雷公藤多甙片副作用的临床观察[J].Guang x i M edical Journal,2002,24(4):576-579 贾春伶.雷公藤不良反应的文献调查与分析[J].北京中医,2006,25(1):45-48 雷公藤