has participant quality kidney AE AE severity G1 AE severity G2 AE severity G3 AE severity G4 AE severity G5 renal calculus AE NCIt: C26807 renal calculi AE Renal calculus AE is a kidney AE that is a solid concretion or crystal aggregation formed in the kidneys from minerals in the urine. Kidney stones typically leave the body by passage in the urine stream, and many stones are formed and passed without causing symptoms. If stones grow to sufficient size (usually at least 3 millimeters (0.12 in)) they can cause blockage of the ureter. This leads to pain, most commonly beginning in the flank or lower back and often radiating to the groin or genitals. 肾结石 kidney stone AE CTCAE: E13018 MedDRA: 10038386; MedDRA: 10038385 WEB: http://en.wikipedia.org/wiki/Kidney_stone nephrolithiasis AE JX, LW, YH