Cisplatin [Chemical/Ingredient] C0008838 cis-Diamminedichloroplatinum(II) cis-Diamminedichloroplatinum C24476 cis-Dichlorodiammineplatinum(II) cis-Platinum 2555 M0004505 Dichlorodiammineplatinum Cisplatin Platinum Diamminodichloride D002945 Cisplatin Platinum, diamminedichloro-, (SP-4-2)- N0000007062 An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Cisplatin Chlorine Compounds [Chemical/Ingredient] Platinum Compounds [Chemical/Ingredient] Nitrogen Compounds [Chemical/Ingredient]