CI_with has_Ingredient has_MoA has_PE may_treat drug associated with AE in adult drug associated with AE in pediatric used to treat disease Thymidylate Synthetase Inhibitors [MoA] Dihydrofolate Reductase Inhibitors [MoA] Arthritis, Juvenile Rheumatoid [Disease/Finding] Blood Coagulation Disorders [Disease/Finding] Breast Neoplasms [Disease/Finding] Drug Hypersensitivity [Disease/Finding] Esophageal Neoplasms [Disease/Finding] Leukemia [Disease/Finding] Liver Diseases, Alcoholic [Disease/Finding] Lung Neoplasms [Disease/Finding] Mycosis Fungoides [Disease/Finding] Neutropenia [Disease/Finding] Psoriasis [Disease/Finding] Osteosarcoma [Disease/Finding] Stomach Neoplasms [Disease/Finding] Testicular Neoplasms [Disease/Finding] Thrombocytopenia [Disease/Finding] Trophoblastic Neoplasms [Disease/Finding] HIV Infections [Disease/Finding] Kidney Failure [Disease/Finding] Methotrexate [Chemical/Ingredient] Decreased DNA Integrity [PE] Pregnancy [Disease/Finding] M [Preparations] METHOTREXATE https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/008085s066lbl.pdf YL5FZ2Y5U1 N0000147916 Ingredient 6851 C0025677 4019828 <VANDF_Record>50.6^254^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>254</VA_IEN> METHOTREXATE C17092 Active <VANDF_Record>50.416^2451^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>2451</VA_IEN> Methotrexate cancer juvenile rheumatoid arthritis rheumatoid arthritis fatigue AE fever AE rash AE headache AE dizziness AE malaise AE chills AE alopecia AE liver function test abnormal AE nausea AE vomiting AE stomatitis AE diarrhea AE leukopenia AE pancytopenia AE thrombocytopenia AE abdominal distress AE