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     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
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     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:obo="http://purl.obolibrary.org/obo/"
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     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
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    <AnnotationProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#FDA_UNII"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
    <AnnotationProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#VANDF_Record"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000412"/>
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    <AnnotationProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#UMLS_CUI"/>
    <AnnotationProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Level"/>
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    <AnnotationProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#VUID"/>
    <AnnotationProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#code"/>
    <AnnotationProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Status"/>
    <AnnotationProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#RxNorm_Name"/>
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    <!-- 
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    <!-- http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_Ingredient -->

    <ObjectProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_Ingredient">
        <rdfs:label>has_Ingredient</rdfs:label>
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    <!-- http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_MoA -->

    <ObjectProperty rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_MoA">
        <rdfs:label>has_MoA</rdfs:label>
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        <rdfs:label>has_PE</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/ODAE_0000005 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/ODAE_0000005">
        <rdfs:label xml:lang="en">drug associated with AE in adult</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/ODAE_0000010 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/ODAE_0000010">
        <rdfs:label xml:lang="en">used to treat disease</rdfs:label>
    </ObjectProperty>
    


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    <!-- http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000000098 -->

    <Class rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000000098">
        <rdfs:label>Thymidylate Synthetase Inhibitors [MoA]</rdfs:label>
    </Class>
    


    <!-- http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000000191 -->

    <Class rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000000191">
        <rdfs:label>Dihydrofolate Reductase Inhibitors [MoA]</rdfs:label>
    </Class>
    


    <!-- http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000008576 -->

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        <rdfs:label>Decreased DNA Integrity [PE]</rdfs:label>
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    <Class rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000010538">
        <rdfs:label>pemetrexed [Chemical/Ingredient]</rdfs:label>
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    <!-- http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000010598 -->

    <Class rdf:about="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000010598">
        <rdfs:label>P [Preparations]</rdfs:label>
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        <rdfs:label>PEMETREXED</rdfs:label>
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        <rdfs:subClassOf>
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        <ns3:Level>Ingredient</ns3:Level>
        <ns3:code>C273299</ns3:code>
        <ns3:FDA_UNII>04Q9AIZ7NO</ns3:FDA_UNII>
        <ns3:Display_Name>PEMETREXED</ns3:Display_Name>
        <ns3:RxNorm_Name>pemetrexed</ns3:RxNorm_Name>
        <ns3:VUID>4021417</ns3:VUID>
        <ns3:UMLS_CUI>C0210657</ns3:UMLS_CUI>
        <ns3:RxNorm_CUI>68446</ns3:RxNorm_CUI>
        <ns3:Status>Active</ns3:Status>
        <ns3:NUI>N0000148831</ns3:NUI>
        <ns3:VANDF_Record>&lt;VANDF_Record&gt;50.416^4093^&lt;/VANDF_Record&gt;&lt;VA_File&gt;50.416&lt;/VA_File&gt;&lt;VA_IEN&gt;4093&lt;/VA_IEN&gt;</ns3:VANDF_Record>
        <ns3:VANDF_Record>&lt;VANDF_Record&gt;50.6^3927^&lt;/VANDF_Record&gt;&lt;VA_File&gt;50.6&lt;/VA_File&gt;&lt;VA_IEN&gt;3927&lt;/VA_IEN&gt;</ns3:VANDF_Record>
        <obo:IAO_0000412 rdf:resource="http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/DOID_3908 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_3908">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">non-small cell lung carcinoma</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/OAE_0000034 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/OAE_0000034">
        <rdfs:label>fatigue AE</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/OAE_0000396 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/OAE_0000396">
        <rdfs:label>anorexia AE</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/OAE_0000600 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/OAE_0000600">
        <rdfs:label>nausea AE</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



