occurs in has participant quality has disease treated with drug INTERFERON ALFA-2A ZIDOVUDINE METHOTREXATE ALDESLEUKIN RITONAVIR TINIDAZOLE cancer hepatitis C renal cell carcinoma human immunodeficiency virus infectious disease amebiasis Child Adult malaise AE 10025482 YH HPO: HP_0002321 CTCAE: E11152 Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise. a sensory capability AE that has an outcome of malaise NCIt: C3832 SIDER: C0231218 sensory capability AE AE severity G1 AE severity G2