homodetic cyclic peptide Cyclosporine cyclosporin A (R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl) 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine] 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone 3008 A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. Antibiotic S 7481F1 Beilstein:3647785 C62H111N11O12 CC[C@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C CHEBI:4031 CHEBI:63586 ChemIDplus:59865-13-3 Ciclosporin CiteXplore:11058832 CiteXplore:11069928 CiteXplore:11079273 CiteXplore:11080188 CiteXplore:11238591 CiteXplore:11256490 CiteXplore:11278005 CiteXplore:11315347 CiteXplore:11370709 CiteXplore:11406057 CiteXplore:11426833 CiteXplore:11442023 CiteXplore:11481617 CiteXplore:11493684 CiteXplore:11529914 CiteXplore:11557554 CiteXplore:11564166 CiteXplore:11676831 CiteXplore:11870366 CiteXplore:12021257 CiteXplore:12050171 CiteXplore:12603598 CiteXplore:12761440 CiteXplore:12929192 CiteXplore:12950728 CiteXplore:14521916 CiteXplore:14621732 CiteXplore:14638917 CiteXplore:14672695 CiteXplore:14682659 CiteXplore:14743390 CiteXplore:15030555 CiteXplore:15175101 CiteXplore:15210365 CiteXplore:15306697 CiteXplore:15383526 CiteXplore:15541012 CiteXplore:15613074 CiteXplore:15626898 CiteXplore:15657176 CiteXplore:1566062 CiteXplore:15711594 CiteXplore:15811524 CiteXplore:15962181 CiteXplore:16372476 CiteXplore:16404634 CiteXplore:16724420 CiteXplore:16801218 CiteXplore:16898534 CiteXplore:17032751 CiteXplore:17083576 CiteXplore:17117422 CiteXplore:17192032 CiteXplore:17220244 CiteXplore:17229932 CiteXplore:17265451 CiteXplore:17446460 CiteXplore:17603747 CiteXplore:18076075 CiteXplore:18171316 CiteXplore:18191430 CiteXplore:18217899 CiteXplore:18259730 CiteXplore:18299432 CiteXplore:18359899 CiteXplore:18583716 CiteXplore:18597363 CiteXplore:18790203 CiteXplore:18818682 CiteXplore:18931077 CiteXplore:18975184 CiteXplore:19282398 CiteXplore:19589783 Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl) Cyclosporin A Cyclosporine DrugBank:DB00091 Gengraf InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42+,43-,44+,45-,46+,47+,49+,50-,51+,52-/m1/s1 InChIKey=PMATZTZNYRCHOR-VJRYSDSKSA-N KEGG COMPOUND:59865-13-3 KEGG COMPOUND:C05086 KEGG DRUG:D00184 Neoral Patent:US4117118 Reaxys:3647785 Sandimmune Wikipedia:Ciclosporin ciclosporin ciclosporina ciclosporine ciclosporinum