purine 2'-deoxyribonucleoside organochlorine compound Cladribine cladribine (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. 2-CdA 2-chloro-2'-deoxy-beta-adenosine 2-chloro-2'-deoxyadenosine 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine 2-chloro-deoxyadenosine 2-chlorodeoxyadenosine 2ClAdo 44157 Beilstein:624220 C10H12ClN5O3 CHEBI:31407 CHEBI:567361 CHEBI:568373 ChEMBL:17526755 ChEMBL:18570408 ChEMBL:567361 ChEMBL:568373 ChemIDplus:4291-63-8 Cladribine CldAdo DrugBank:DB00242 InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1 InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N KEGG DRUG:4291-63-8 KEGG DRUG:D01370 Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1 Patent:EP173059 Patent:US4760137 Wikipedia:Cladribine cladribina cladribine cladribinum