diamine Pergolide pergolide (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline 8047 A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction. C19H26N2S CHEBI:63617 CHEBI:8020 ChemIDplus:66104-22-1 CiteXplore:11852289 CiteXplore:15180134 CiteXplore:16845152 CiteXplore:18071034 CiteXplore:2012117 DrugBank:DB01186 InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 InChIKey=YEHCICAEULNIGD-MZMPZRCHSA-N KEGG COMPOUND:66104-22-1 KEGG COMPOUND:C07425 KEGG DRUG:D08339 Patent:US4166182 Reaxys:5091461 Wikipedia:Pergolide [H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CSC)CN2CCC pergolida pergolide pergolidum