pyranoindolizinoquinoline Topotecan topotecan (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 57308 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. C23H23N3O5 CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O CHEBI:63632 CHEBI:9634 ChemIDplus:123948-87-8 CiteXplore:20574789 CiteXplore:21255983 CiteXplore:21352915 CiteXplore:21910214 CiteXplore:22028494 CiteXplore:22075006 CiteXplore:22136714 CiteXplore:22190039 DrugBank:DB01030 InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1 InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N KEGG COMPOUND:123948-87-8 KEGG COMPOUND:C11158 KEGG DRUG:D08618 Patent:EP321122 Reaxys:4279441 Topotecan Wikipedia:Topotecan topotecan topotecane topotecanum