regulation of transcription, DNA-templated regulation of sequence-specific DNA binding transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. GO:0051090 Reactome:REACT_104536 Reactome:REACT_107559 Reactome:REACT_109535 Reactome:REACT_110257 Reactome:REACT_110693 Reactome:REACT_21326 Reactome:REACT_82719 Reactome:REACT_83365 Reactome:REACT_90659 Reactome:REACT_92725 Reactome:REACT_96476 Reactome:REACT_99415 biological_process regulation of transcription factor activity regulation of molecular function