ICOP causally related to genetic disorder periodontal pain due to periodontitis as a manifestation of a systemic disorder periodontal pain due to genetic disorder 2025-06-26T18:54:59Z ICOP number: 1.1.2.1.3.3.2 Periodontal pain due to periodontitis as a manifestion of a systematic genetic disorder. Genetic disorders which can result in periodontitis include familial and cyclic neutropenia, Down syndrome, leukocyte adhesion deficiency syndromes, Papillon–Lefèvre syndrome, Chediak–Higashi syndrome, histiocytosis syndromes, glycogen storage disease, infantile genetic agranulocytosis, Cohen syndrome, Ehler–Danlos syndrome (types IV and VIII), and hypophosphatasia. PMID:32103673 Finn Wilson Ava E. Cunningham