has microbe depleted in diseased host Actinobacillus bacterial change in lung of severe COPD patient compared to mild-moderate COPD depletion of Actinobacillus in lung of severe COPD patient compared to mild-moderate COPD Yongqun He Yang Wang PMID:25253795 Actinobacillus down-regulated in the lung of severe COPD patient compared to mild-moderate COPD. Jie Zheng