has role has_role has role gene as virulence factor in pathogen has role has_role has role Human immunodeficiency virus 1 protein-coding gene of Human immunodeficiency virus 1 vpr 11676 155807 20140406 Bin Zhao, Oliver He HIV1gp4 NCBI-supplied Other designations: Vpr PMID: 7474080; 7474100; 7494303; 7592727; 7666531; 7724608; 8195203; 8551605; 8800208; 9013886; 9094673; 9151883; 9188632; 9199338; 9261351; 9334723; 9362478; 9371639; 9436978; 9449720; 9463369; 9520381; 9525626; 9525900; 9560267; 9582382; 9621063; 9636371; 9685344; 9817747; 9846873; 9874563; 9882380; 10359081; 10438581; 10561576; 10620603; 10708425; 10713718; 10772949; 10775602; 10888643; 10888660; 10931842; 10933727; 10958988; 10964507; 10985253; 11000244; 11024150; 11087358; 11152524; 11175251; 11181702; 11193032; 11196199; 11223251; 11259200; 11426943; 11437653; 11531413; 11689055; 11691994; 11878934; 11935461; 12079361; 12084067; 12095993; 12096338; 12208951; 12228227; 12237292; 12359436; 12379213; 12404120; 12444143; 12457980; 12504543; 12510154; 12525641; 12525642; 12573582; 12634356; 12639957; 12642036; 12738771; 12750393; 12750404; 12788643; 12805458; 12853482; 12881522; 12881523; 14506268; 14751250; 14767062; 14972559; 15063744; 15096517; 15142377; 15142379; 15142380; 15142381; 15142382; 15166037; 15254189; 15265780; 15294897; 15302882; 15331702; 15353294; 15380361; 15449141; 15485898; 15578586; 15578977; 15611322; 15616007; 15638722; 15650754; 15659641; 15708996; 15725353; 15731250; 15780175; 15817944; 15832179; 15956545; 16103149; 16103171; 16103188; 16120388; 16243842; 16305395; 16306615; 16337983; 16338743; 16354571; 16429131; 16480911; 16492162; 16492778; 16511342; 16520893; 16571786; 16877301; 16923959; 16950655; 16956949; 16968670; 16969134; 16983346; 17020411; 17023015; 17090531; 17140287; 17172832; 17176760; 17210576; 17254575; 17304248; 17314515; 17328670; 17331040; 17344301; 17347016; 17349711; 17360488; 17409234; 17433108; 17475642; 17553868; 17553871; 17559673; 17560997; 17586316; 17586317; 17609381; 17620334; 17622316; 17626091; 17630831; 17652391; 17824250; 17855541; 17932108; 17967742; 18039376; 18060429; 18061232; 18082865; 18094160; 18160429; 18187620; 18220834; 18275585; 18295813; 18385244; 18414671; 18414697; 18417583; 18434400; 18445273; 18514189; 18524771; 18541215; 18577246; 18606781; 18614999; 18638397; 18829761; 18987145; 19013323; 19020832; 19149577; 19160543; 19204000; 19254034; 19275579; 19275580; 19275582; 19275583; 19275584; 19275585; 19275586; 19275587; 19275588; 19328187; 19338763; 19344781; 19458171; 19516896; 19559726; 19581932; 19625402; 19629466; 19655254; 19657269; 19667756; 19674438; 19692467; 19696076; 19726511; 19798433; 19803398; 19838296; 19883084; 19895210; 19925402; 20008788; 20012529; 20015032; 20018238; 20069611; 20089662; 20097875; 20145198; 20347598; 20380698; 20380700; 20392842; 20404718; 20446002; 20529298; 20558198; 20609246; 20614012; 20628092; 20628645; 20685659; 20719241; 20801175; 20824083; 20870715; 20877724; 20920334; 21072166; 21084468; 21318276; 21411754; 21489275; 21519849; 21526938; 21566118; 21645334; 21651489; 21704113; 21763498; 21816823; 21827382; 21874023; 21875947; 21918813; 21934670; 21957298; 21994772; 22023789; 22077140; 22094081; 22110766; 22171270; 22185200; 22190034; 22190037; 22274659; 22292079; 22403404; 22422068; 22438978; 22457629; 22509482; 22552851; 22590503; 22720156; 22727020; 22776683; 22832123; 23001849; 23017337; 23255807; 23453579; 23467037; 23612978; 23726848; 23842279; 23849790; 23874603; 24045107; 24116224; 24178031 WEB: http://www.ncbi.nlm.nih.gov/gene p15 protein-coding MUTATION: T cell infections using vesicular stomatitis virus G (VSV-G) pseudotyped HIV-1 Vpr R77Q result in less (P = 0.01) T cell death than infections using wild-type Vpr, despite similar levels of viral replication. Wild-type Vpr-associated events, including procaspase-8 and -3 cleavage, loss of mitochondrial transmembrane potential (deltapsi(m)), and DNA fragmentation factor activation are attenuated by R77Q Vpr. There is also a higher frequency of R77Q Vpr mutations in patients with LTNP than in patients with progressive disease [PMID:12750404]. 1919 virulence factor gene role