has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host gene encoding antigen has role has_role has role Mus musculus Mus musculus 小家鼠 Human immunodeficiency virus 1 protein-coding gene of Human immunodeficiency virus 1 nef 11676 156110 20140406 Bin Zhao, Oliver He HIV1gp9 NCBI-supplied Other designations: Nef PMID: 1527859; 1565858; 2014052; 2052609; 3118220; 7540194; 7588629; 7769669; 7797518; 7831289; 7853525; 7859737; 7871751; 7884893; 7902127; 7903128; 7912927; 7975260; 7982906; 7983750; 8035515; 8057354; 8086129; 8102828; 8108442; 8124721; 8151774; 8151786; 8178481; 8262036; 8331733; 8437228; 8480425; 8516299; 8598486; 8599214; 8599229; 8599760; 8612235; 8626429; 8636073; 8663223; 8681387; 8709227; 8709241; 8709288; 8765022; 8769094; 8794306; 8862424; 8871625; 8939608; 8994833; 9017839; 9032396; 9049297; 9049329; 9052838; 9070423; 9075929; 9096366; 9108086; 9110068; 9123874; 9139671; 9153233; 9168885; 9218412; 9247029; 9288906; 9299485; 9314527; 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22479639; 22496420; 22534017; 22537596; 22553319; 22583022; 22613796; 22640559; 22643973; 22651890; 22655069; 22672539; 22705789; 22721673; 22767237; 22802418; 22808111; 22826228; 22844345; 22980332; 22980333; 23067370; 23071112; 23093676; 23151229; 23170180; 23185362; 23284715; 23417613; 23490051; 23678182; 23746211; 23799149; 23855121; 23899341; 24051604; 24489825 WEB: http://www.ncbi.nlm.nih.gov/gene p27 protein-coding 1920 MUTATION: HIV-1 replication in vivo can be separated from its pathogenic activity, in that the HXB/LW virus replicated to high levels in SCID-hu Thy/Liv mice, with no significant thymocyte depletion. Restoration of the nef gene in the recombinant HXB/LW genome restored its pathogenic activity, with no significant effect on HIV-1 replication in the thymus. Implicating nef as a determinant of pathogenicity [PMID:11264380]. virulence factor gene role Nef