has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host cell line cell gene mutant attenuated in host cell gene mutant attenuated in host has role has_role has role HeLa cell HeLa cell HeLa 细胞 macrophage macrophage 巨噬细胞 Mus musculus Mus musculus 小家鼠 Yersinia pestis KIM10+ gene MUTATION: yopB mutant is avirulent in mouse model, fails to elicit a cytotoxic response in cultured HeLa cells and is unable to inhibit phagocytosis by macrophage-like J774 cells [PMID:8918459]. 2526 virulence factor gene role