has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host cell gene mutant attenuated in host has role has_role has role macrophage macrophage 巨噬细胞 Brucella suis 1330 Homo sapiens Homo sapiens 人类 protein-coding gene of Brucella suis 1330 eryB 1165308 20140406 204722 BRA0865 Bin Zhao, Oliver He II NCBI-supplied PMID: 12271122 WEB: http://www.ncbi.nlm.nih.gov/gene glycerol-3-phosphate dehydrogenase protein-coding 1011 MUTATION: EryB is an erythritol phosphate dehydrogenase. The vaccine strain B abortus B19 is the only known B abortus isolate whose growth is inhibited by erythritol. The B abortus B19 strain is an eryCD double mutant. The defect in B19 was complemented in trans by plasmids containing the complete ery region and by plasmids with Tn1725 insertions in eryA, eryB and eryD. Plasmids with Tn1725 insertions in eryC were the only ones that failed to complement the Ery phenotype of B19 [PMID:10708387]. The B. suis eryB mutant by Tn5 transposon mutagenesis was attenuated in the human macrophage -like THP-1 cells. This mutant is sensitive to erythritol and mimics the erythritol sensitive response of the B19 strain [PMID:10708387]. virulence factor gene role