has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host cell gene mutant attenuated in host has role has_role has role epithelial cell epithelial cell 上皮细胞 Mus musculus Mus musculus 小家鼠 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 protein-coding gene of Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 sptP 1254401 20140405 99287 Bin Zhao, Oliver He NCBI-supplied PMID: 11677609; 19286132; 21801239; 24332031 STM2878 WEB: http://www.ncbi.nlm.nih.gov/gene protein tyrosine phosphatase/GTPase activating protein protein-coding 2751 MUTATION: sptP mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type. Competition experiments indicate that sptP mutants fail to colonize the spleen of mice when coinoculated with wild-type S. enterica [PMID:15182677]. virulence factor gene role