has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host has role has_role has role Mus musculus Mus musculus 小家鼠 Cowpox virus Oryctolagus cuniculus protein-coding gene of Cowpox virus VGF 10243 1485896 20121122 Bin Zhao, Oliver He CPXV021 NCBI-supplied Other designations: CPXV021 protein or CPXV VGF protein PMID: 2014645; 2309453; 6961398; 8091665 WEB: http://www.ncbi.nlm.nih.gov/gene protein-coding similar to viral growth factor (C11R vaccinia virus Copenhagen) 5035 MUTATION: Higher doses of VGF- virus than WT virus were required for intracranial lethality in mice and for production of skin lesions in rabbits. Thus, expression of the VGF gene is important to the virulence of vaccinia virus [PMID:3339716]. virulence factor gene role