has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host cell gene mutant attenuated in host has role has_role has role epithelial cell epithelial cell 上皮细胞 Mus musculus Mus musculus 小家鼠 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 gene 1644 MUTATION: sptP mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type. Competition experiments indicate that sptP mutants fail to colonize the spleen of mice when coinoculated with wild-type S. enterica [PMID:15182677]. virulence factor gene role