has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host cell line cell gene mutant attenuated in host has role has_role has role HeLa cell HeLa cell HeLa 细胞 Mus musculus Mus musculus 小家鼠 Brucella abortus 2308 Brucella melitensis biovar Abortus 2308 protein-coding gene of Brucella melitensis biovar Abortus 2308 gnd 20140405 359391 3828241 6-phosphogluconate dehydrogenase BAB2_0109 Bin Zhao, Oliver He II NCBI-supplied PMID: 16299333 WEB: http://www.ncbi.nlm.nih.gov/gene protein-coding MUTATION: gnd is involved in pentose phosphate pathway. It is essential for intracellular growth inside HeLa cells as shown by its Brucella suis miniTn5Km2 transposon mutation analysis. The mutant is attenuated in the mouse model [PMID:12761078]. 1771 virulence factor gene role