has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host cell gene mutant attenuated in host has role has_role has role macrophage macrophage 巨噬细胞 Mus musculus Mus musculus 小家鼠 Yersinia pestis Angola protein-coding gene of Yersinia pestis Angola phoP 20140222 349746 5801327 Bin Zhao, Oliver He DNA-binding transcriptional regulator PhoP NCBI-supplied PMID: 20061468 WEB: http://www.ncbi.nlm.nih.gov/gene YpAngola_A2855 protein-coding 1954 MUTATION: phoP mutants have a reduced ability to survive in J774 macrophage cell cultures and under conditions of low pH and oxidative stress in vitro. The mean lethal dose of the phoP mutant in mice was increased 75-fold in comparison with that of the wild-type strain [PMID:10816493]. virulence factor gene role