has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host cell gene mutant attenuated in host gene encoding antigen has role has_role has role epithelial cell epithelial cell 上皮细胞 Mus musculus Mus musculus 小家鼠 Streptococcus pneumoniae ATCC 700669 Homo sapiens Homo sapiens 人类 protein-coding gene of Streptococcus pneumoniae ATCC 700669 psrP 20140215 561276 7329552 Bin Zhao, Oliver He NCBI-supplied PMID: 19114491; 19627498; 20714350 SPN23F_17820 WEB: http://www.ncbi.nlm.nih.gov/gene cell wall surface anchored protein protein-coding MUTATION: psrP mutants failed to bind to A549 and LA-4 lung cells, yet adhered normally to human nasopharyngeal epithelial cells and to cells from human and rodent capillary endothelial cell lines. psrP mutants were also unable to persist in the lungs of mice [PMID:18507531]. 3631 virulence factor gene role PsrP