has role has_role has role gene as virulence factor in pathogen gene mutant attenuated in host cell gene mutant attenuated in host has role has_role has role macrophage macrophage 巨噬细胞 Mus musculus Mus musculus 小家鼠 Cryptococcus neoformans var. grubii H99 gene MUTATION: The gta1 mutant exhibited impaired growth on all amino acids tested as sole nitrogen sources, with the exception of arginine and proline. Gat1 is not required for C. neoformans survival during macrophage infection or for virulence in a mouse model of cryptococcosis [PMID:20673806][PMID:20673806]. 5307 virulence factor gene role