has role has_role has role gene as virulence factor in pathogen has role has_role has role Cryptococcus neoformans var. grubii H99 gene MUTATION: RDI1-overexpressing strains exhibited altered morphology compared to that of the wild type, with apparent defects in maintaining proper cell polarity and cytokinesis. RDI1 deletion resulted in increased vacuole size in tissue culture medium and aberrant cell morphology at neutral pH [PMID:18779335]. 5355 virulence factor gene role