has role has_role has role gene as virulence factor in pathogen has role has_role has role Cryptococcus neoformans var. grubii H99 gene MUTATION: Δarg1 mutants had impaired thermotolerance, compromised cell walls, reduced capsule production and melanization, defective cell separation, and the inability to form mating filaments and attenuated homeostasis and virulence in the Galleria mellonella infection model [PMID:23381992]. 5267 virulence factor gene role