part of part_of part of part_of develops_from develops from developmentally_induced_by developmentally induced by connected anatomical structure tissue neurectoderm eye primordium ectoderm-derived structure optic vesicle (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG] AAO:0011039 EHDAA2:0001320 EMAPA:16540 FMA:293357 Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288] NCIT:C34236 TAO:0000050 The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. UBERON:0004128 UMLS:C0231106 VHOG:0000165 XAO:0000228 ZFA:0000050 evagination eye vesicle ocular vesicle optic vesicles uberon chordamesoderm immature eye