macromolecule metabolic process cellular metabolic process cellular macromolecule metabolic process GO:0034960 GO:0044260 The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. biological_process cellular biopolymer metabolic process cellular macromolecule metabolism