protein complex GAIT complex 2012-12-19T09:32:25Z A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. GO:0097452 IFN-gamma-activated inhibitor of translation complex cellular_component gamma interferon-activated inhibitor of translation complex go.owl paola pro.owl