growth factor complex platelet-derived growth factor complex 2014-01-09T16:09:11Z A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD). An example of this is PDGFA in human (P04085) in PMID:20534510 (inferred from direct assay). GO:1990265 IntAct:EBI-2881436 IntAct:EBI-2881443 IntAct:EBI-2881451 PDGF complex PDGF-AA dimer PDGF-AB dimer PDGF-BB dimer PDGF-CC dimer PDGF-DD dimer bhm cellular_component go.owl pro.owl