assay for transposase-accessible chromatin using sequencing single-nucleus ATAC-seq An ATAC-seq assay in which single nuclei are isolated from frozen tissue samples, through a protocol designed to maximally preserve nucleus integrity during sample processing and optimize transposase-mediated fragmentation of chromatin in individual nuclei. ENCODE Mark Andrew Miller, ORCID:0000-0001-9076-6066 http://www.biorxiv.org/content/early/2017/07/06/159137 https://github.com/obi-ontology/obi/issues/864 snATAC-seq snATAC-seq can be used to dissect heterogeneity and delineate gene regulatory sequences in complex tissues, and uncover both the cell types and the regulatory elements in each cell type without prior knowledge. single-nucleus ATAC-seq metadata complete