repeated measure design cross over design (source: http://www.sbu.se/Filer/Content0/publikationer/1/literaturesearching_1993/glossary.html) a repeated measure design which ensures that experimental units receive, in sequence, the treatment (or the control), and then, after a specified time interval (aka *wash-out periods*), switch to the control (or treatment). In this design, subjects (patients in human context) serve as their own controls, and randomization may be used to determine the ordering which a subject receives the treatment and control cross over design metadata complete