develops from fibroblast A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. A connective-tissue cell of mesenchymal origin that secretes proteins and especially molecular collagen from which the extracellular fibrillar matrix of connective tissue forms. A large, flat, oval cell found in connective tissue and responsible for the formation of fibers. BTO:0000452 BTO:0000452 CALOHA:TS-0362 CL:0000057 EFO_URI: http://www.ebi.ac.uk/efo/EFO_0000496 FMA:63877 James Malone NIFSTD:nlx_cell_20090201 These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. Tomasz Adamusiak URI: http://www.ebi.ac.uk/cellline#fibroblast VHOG:0001482 cell mouse embryonic fibroblast primary dermal fibroblast mesenchymal stem cell connective tissue cell