has part has part bounding layer of surrounded_by existence ends during fully formed stage anatomical system multicellular organism integumental system (...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG] AEO:0000154 BILA:0000118 CALOHA:TS-1299 CARO:0002001 Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. EFO:0000807 EHDAA2:0000836 EHDAA2_RETIRED:0003154 EHDAA:6520 EMAPA:17524 EV:0100151 FBbt:00004969 FMA:72979 HAO:0000421 MA:0000014 MAT:0000033 MESH:D034582 MIAA:0000033 TADS:0000108 UBERON:0002416 UBERON:0007029 UMLS:C0037267 VHOG:0000403 XAO:0000176 body surface dermal system external covering of organism galen:Surface integumentary system integumentum commune organism surface surface uberon outer epithelium space surrounding organism