<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/PATO?iri=http://purl.obolibrary.org/obo/CL_0000037"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:cl="http://purl.obolibrary.org/obo/cl#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/cl#cellxgene_subset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0002202 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002202">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label xml:lang="en">develops from</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002215 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002215">
        <rdfs:label xml:lang="en">capable of</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CL_0000037 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000037">
        <rdfs:label>hematopoietic stem cell</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000255"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000723"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0008001"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0011026"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002202"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CL_0000566"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0002244"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasExactSynonym>hemopoietic stem cell</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>FMA:86475</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>BTO:0000725</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CALOHA:TS-0448</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>colony forming unit hematopoietic</oboInOwl:hasRelatedSynonym>
        <rdfs:comment>Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.</rdfs:comment>
        <oboInOwl:hasDbXref>VHOG:0001485</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>blood forming stem cell</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>MESH:D006412</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.</ns4:IAO_0000115>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#cellxgene_subset"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000255 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000255">
        <rdfs:label>eukaryotic cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000566 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000566">
        <rdfs:label>angioblastic mesenchymal cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000723 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000723">
        <rdfs:label>somatic stem cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0008001 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0008001">
        <rdfs:label>hematopoietic precursor cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0011026 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0011026">
        <rdfs:label>progenitor cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0002244 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/GO_0002244">
        <rdfs:label>hematopoietic progenitor cell differentiation</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



