has participant chemical synaptic transmission biological_process Reactome:R-HSA-9619229 signal transmission across a synapse Reactome:R-HSA-442729 GO:0007268 Reactome:R-HSA-9620244 Wikipedia:Neurotransmission Reactome:R-HSA-112316 Reactome:R-HSA-442742 Reactome:R-HSA-442720 neurotransmission Reactome:R-HSA-451307 synaptic transmission Reactome:R-HSA-9619483 Reactome:R-HSA-451308 The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. synapse anterograde trans-synaptic signaling